21 CFR 1306.12
- Prescriptions for schedule II controlled substances cannot be refilled
21 CFR 1306.13
Prescriptions for schedule II have no specific time limitations on dispensing after the prescription is issued other than 60 days if the patient is in a long term care facility or has a medical diagnosis documenting a terminal
State specific limitations vary on dispensing time from date of issuance for schedule II: e.g., Virginia's is 6 months and Hawaii's is 7 days.
21 CFR 1306.22
- Prescriptions for Schedule III and IV controlled substances cannot be dispensed after 6 months from date of issue or refilled more than 5 times
- Rules for refilling Schedule V controlled substances are not established by federal law, and the authorized number of refills depends on the professional judgment of the prescriber and the pharmacist